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However, such drugs are not causes of B12 deficiency

[5] Alba et al

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Research has shown that blocking NNMT can reduce lipogenesis by 50 to 70 percent in adipocytes compared to untreated controls

Methodologically, GHK-Cu research has used cell-culture systems (primarily fibroblasts, keratinocytes, and dermal papilla cells), animal models (rodent wound-healing models predominantly), human clinical-research studies in cosmetic contexts, and analytical biochemistry approaches